Wrench I J, Ward J E, Walder A D, Hobbs G J
University Department of Anaesthesia, Queen's Medical Centre, Nottingham.
Anaesthesia. 1996 Aug;51(8):776-8. doi: 10.1111/j.1365-2044.1996.tb07895.x.
We have studied the effect of combination antiemetic therapy (ondansetron and droperidol) with morphine delivered by patient-controlled analgesia following major gynaecological surgery. Sixty patients were randomly allocated to one of three treatment regimens; ondansetron alone (4 mg bolus and 0.13 mg.ml-1 in the morphine solution), droperidol alone (1.25 mg bolus and 0.05 mg.ml-1 in the morphine solution), or both drugs in combination. For the first 12 postoperative hours, patients receiving combination therapy experienced significantly less nausea than those receiving single antiemetic therapy (p < 0.001). There was no difference between the regimens from 12 to 18 h. We conclude that a combination of ondansetron and droperidol added to morphine in a patient-controlled analgesia system reduces postoperative nausea to a greater extent than treatment with either drug alone following major gynaecological surgery.
我们研究了在大型妇科手术后，联合使用止吐疗法（昂丹司琼和氟哌利多）与患者自控镇痛泵输注吗啡的效果。60例患者被随机分配至三种治疗方案之一：单独使用昂丹司琼（4mg推注剂量，吗啡溶液中浓度为0.13mg/ml）、单独使用氟哌利多（1.25mg推注剂量，吗啡溶液中浓度为0.05mg/ml）或两种药物联合使用。术后前12小时，接受联合治疗的患者恶心症状明显少于接受单一止吐治疗的患者（p<0.001）。12至18小时各治疗方案之间无差异。我们得出结论，在患者自控镇痛系统中，将昂丹司琼和氟哌利多与吗啡联合使用，比大型妇科手术后单独使用任一药物能更大程度地减轻术后恶心症状。
