新生儿重症监护病房中的经皮胆红素测定法。
Transcutaneous bilirubinometry in neonatal intensive care units.
作者信息
Knudsen A, Ebbesen F
机构信息
Department of Neonatology, University Hospital, Aalborg, Denmark.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1996 Jul;75(1):F53-6. doi: 10.1136/fn.75.1.f53.
AIMS
To study the influence of several clinical and paraclinical factors on the association between jaundice meter readings and plasma bilirubin concentration; and to comment on the usefulness of the jaundice meter as a screening device for hyperbilirubinaemia in neonatal intensive care units.
METHODS
Three hundred and seventy seven newborn babies admitted to the neonatal intensive care unit for various causes were included in the study. When the plasma bilirubin concentration needed to be determined for clinical reasons, the extent of the yellow skin colour was measured transcutaneously, using a jaundice meter. The haemoglobin concentration was also determined. This had no independent influence on the jaundice meter readings. The yellow skin colour was significantly and positively correlated with the bilirubin concentration and the presence of respiratory distress syndrome (RDS), and negatively with gestational age and postnatal ages.
CONCLUSIONS
These findings were interpreted as being due to variations in the ability of albumin to bind bilirubin, and in the basal yellow skin colour. It was impossible to derive simple criteria for detection of hyperbilirubinemia by jaundice meter readings in this study group.
目的
研究多种临床和临床旁因素对黄疸仪读数与血浆胆红素浓度之间关联的影响；并对黄疸仪作为新生儿重症监护病房高胆红素血症筛查工具的实用性进行评价。
方法
本研究纳入了377名因各种原因入住新生儿重症监护病房的新生儿。当出于临床原因需要测定血浆胆红素浓度时，使用黄疸仪经皮测量皮肤黄疸程度。同时也测定了血红蛋白浓度，其对黄疸仪读数无独立影响。皮肤黄疸程度与胆红素浓度及呼吸窘迫综合征（RDS）的存在呈显著正相关，与胎龄和出生后年龄呈负相关。
结论
这些发现被解释为是由于白蛋白结合胆红素的能力以及基础皮肤黄疸颜色存在差异所致。在该研究组中，无法通过黄疸仪读数得出检测高胆红素血症的简单标准。
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