Schmitt D A, Sonnenfeld G, Husson D, Tkaczuk J, André E, Schaffar L
Laboratoire d'Immunologie, Faculté de Médecine et CHU Rangueil, Toulouse, France.
Life Sci. 1996;59(11):931-7. doi: 10.1016/0024-3205(96)00391-8.
Anti-human monoclonal antibodies were used to detect and quantify interleukins-1 and 2 and interleukin-2 receptor expression in peripheral blood mononuclear cells from a rhesus monkey. Interleukin-1 production could be induced by phorbol esters (PMA) and was potentiated by phytohemagglutinin (PHA). Interleukin-2 secretion could also be induced by the combination of PHA and PMA, but only weakly with PHA alone. Interleukin-2 receptor expression was present in a subpopulation of unstimulated lymphocytes and could be enhanced by PHA or PMA. These data show once again that the rhesus monkey immune system is cross-reactive with the human one and that rhesus macaque could be a good model to study interleukin therapy.
使用抗人单克隆抗体检测并定量恒河猴外周血单个核细胞中白细胞介素-1、白细胞介素-2以及白细胞介素-2受体的表达。佛波酯（PMA）可诱导白细胞介素-1的产生，植物血凝素（PHA）可增强其产生。PHA与PMA联合使用也可诱导白细胞介素-2的分泌，但单独使用PHA时诱导作用较弱。白细胞介素-2受体表达存在于未受刺激的淋巴细胞亚群中，PHA或PMA可增强其表达。这些数据再次表明，恒河猴免疫系统与人的免疫系统具有交叉反应性，恒河猴可能是研究白细胞介素治疗的良好模型。
