Komorous J M, Wheeler C E, Briggaman R A, Caro I
Arch Dermatol. 1977 Jul;113(7):918-22.
Most dermatologists are familiar with the manifestations of neonatal herpes simplex infections. Few, however, are acquainted with the concept of intrauterine herpes simplex infections. This article describes two additional cases of intrauterine herpes simplex infections with congenital malformations. Common features included intrauterine growth retardation, microcephaly, encephalitis, chorioretinitis, psychomotor retardation, and recurrent, grouped, cutaneous vesicles. Seven similar cases with congenital malformations are reviewed as well as cases of intrauterine herpes simplex infection without congenital malformations. We propose that intrauterine herpes simplex infections be termed "early" when there is evidence of disturbed embryogenesis or "late" when congenital malformations are less specific or inapparent. We further suggest that the spectrum of intrauterine infections is similar to that of neonatally acquired infections.
大多数皮肤科医生都熟悉新生儿单纯疱疹感染的表现。然而，很少有人了解宫内单纯疱疹感染的概念。本文描述了另外两例伴有先天性畸形的宫内单纯疱疹感染病例。常见特征包括宫内生长迟缓、小头畸形、脑炎、脉络膜视网膜炎、精神运动发育迟缓以及反复发作的、成簇的皮肤水疱。我们还回顾了7例类似的伴有先天性畸形的病例以及无先天性畸形的宫内单纯疱疹感染病例。我们建议，当有胚胎发育紊乱的证据时，宫内单纯疱疹感染应称为“早期”感染；当先天性畸形不太明确或不明显时，则称为“晚期”感染。我们进一步认为，宫内感染的范围与新生儿获得性感染相似。
