Johansson A-B, Rassart A, Blum D, Van Beers D, Liesnard Corinne
Neonatal Intensive Care Unit, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium.
Clin Infect Dis. 2004 Apr 1;38(7):e57-62. doi: 10.1086/382673. Epub 2004 Mar 12.
A neonate with lower-limb hypoplasia, cutaneous scars, bilateral chorioretinitis, and multiple brain abnormalities is presented. Intrauterine herpes simplex virus type 2 (HSV-2) infection was established on the basis of serological testing of the mother and viral cultures of the child's cutaneous lesions, obtained soon after birth. This is, to the best of our knowledge, the first case of a patient with in utero-acquired HSV-2 infection presenting with a limb hypoplasia. It illustrates that, in addition to congenital varicella-zoster syndrome, HSV-2 infection should also be considered in patients presenting with limb hypoplasia.
本文报告了一名患有下肢发育不全、皮肤瘢痕、双侧脉络膜视网膜炎和多种脑部异常的新生儿。根据母亲的血清学检测以及出生后不久获得的患儿皮肤病变的病毒培养结果，确诊为宫内2型单纯疱疹病毒（HSV-2）感染。据我们所知，这是首例宫内获得性HSV-2感染且伴有肢体发育不全的患者。这表明，除先天性水痘-带状疱疹综合征外，对于出现肢体发育不全的患者，也应考虑HSV-2感染。
