Wender P H, Rosenthal D, Rainer J D, Greenhill L, Sarlin M B
Arch Gen Psychiatry. 1977 Jul;34(7):777-84. doi: 10.1001/archpsyc.1977.01770190039003.
With the exception of one finding in one experiment, adoption studies have demonstrated that genetic and not rearing factors play an etiological role in the schizophrenias. In that one study, clinical evaluations showed the biological parents of schizophrenics as more disturbed than the adopting parents of schizophrenics, who were, in turn, slightly more disturbed than the adopting parents of normal persons. Both the biological and the adopting parents of schizophrenics showed an equivalent degree of Rorschach pathology, suggesting the possible role of a learned communication disorder in the schizophrenic disorders. A replicative study were performed, employing the same design but utilizing a systematic sample. Structured interviews and tests were administered to the biological parents of nongenetic retardates. Structured clinical evaluation showed the biological parents of schizophrenics to be more disturbed than the other two groups, between whom there was no difference in psychopathology. With analysis of the Rorschach tests, the biological parents of schizophrenics showed significantly more Rorschach pathology than found in the other two groups, whose degree of disorder was the same. This study again confirms the role of genetic factors and fails to show an environmental component in the etiology of the schizophrenias.
除了一项实验中的一个发现外,收养研究表明,在精神分裂症的病因中起作用的是遗传因素而非养育因素。在那项研究中,临床评估显示,精神分裂症患者的生物学父母比其养父母更紊乱,而其养父母又比正常人的养父母略为紊乱。精神分裂症患者的生物学父母和养父母在罗夏测验病理学方面表现出同等程度,这表明习得性沟通障碍在精神分裂症中可能发挥作用。进行了一项重复性研究,采用相同设计但使用系统样本。对非遗传性智力迟钝者的生物学父母进行了结构化访谈和测试。结构化临床评估显示,精神分裂症患者的生物学父母比其他两组更紊乱,而后两组在精神病理学方面没有差异。通过对罗夏测验的分析,精神分裂症患者的生物学父母在罗夏测验病理学方面比其他两组显著更严重,而后两组的紊乱程度相同。这项研究再次证实了遗传因素的作用,并未显示出精神分裂症病因中的环境因素。