Tienari P
Department of Psychiatry, University of Oulu, Finland.
Acta Psychiatr Scand. 1991 Nov;84(5):460-5. doi: 10.1111/j.1600-0447.1991.tb03178.x.
A nationwide Finnish sample of schizophrenics' offspring given up for adoption was compared blindly with matched controls, that is, adopted-away offspring of nonschizophrenic biologic parents. The adoptive families were investigated thoroughly by joint and individual interviews and psychologic tests. Biologic parents were also interviewed and tested. Among the 144 index and 178 control offspring, the percentage of both psychoses and other severe diagnoses (borderline syndrome and severe personality disorder) was significantly higher in the index adoptees than in the matched control adoptees. Of the 15 psychotic adoptees in the total sample to date, 13 are offspring of schizophrenics and 2 are control offspring. Both global clinical ratings and test data for the adoptive, rearing parents also correlate with the symptomatic status of the adoptees. A prospective, longitudinal study of adoptees at risk is being undertaken to explore the direction of effects between adoptees and adoptive parents.
对芬兰全国范围内放弃领养的精神分裂症患者后代样本与匹配的对照组进行了盲法比较，对照组即非精神分裂症生物学父母的领养后代。通过联合访谈、个别访谈和心理测试对领养家庭进行了全面调查。对生物学父母也进行了访谈和测试。在144名索引领养者和178名对照领养者中，索引领养者中患精神病和其他严重诊断（边缘性综合征和严重人格障碍）的百分比显著高于匹配的对照领养者。在迄今为止的总样本中的15名患精神病的领养者中，13名是精神分裂症患者的后代，2名是对照后代。领养、抚养父母的总体临床评分和测试数据也与领养者的症状状态相关。正在对有风险的领养者进行一项前瞻性纵向研究，以探索领养者与领养父母之间影响方向。
