Grevert P, Masover B, Goldstein A
Arch Gen Psychiatry. 1977 Jul;34(7):849-53. doi: 10.1001/archpsyc.1977.01770190111011.
Memory tests were administered to 30 patients taking methadone hydrochloride and 31 taking levomethadyl acetate (levo-alpha-acetylmethadol, LAAM) both prior to treatment and after one and three months of continuous treatment. A group of nonopiate using matched control subjects was administered the tests at similar intervals. No statistically significant difference in test performance was found among these groups at any of the three sessions. The methadone and control groups also did not differ significantly in the frequency of subjective reports of decreased memory function. Previous reports of memory deflicits during long-term methadone administration may be a result of comparing methadone and control groups at a single point in time and assuming that prior to methadone maintenance the groups were equivalent.
对30名服用盐酸美沙酮的患者和31名服用醋酸左美沙朵（左旋 - α - 乙酰美沙醇，LAAM）的患者在治疗前以及持续治疗1个月和3个月后进行了记忆测试。一组未使用阿片类药物的匹配对照组受试者在相似的时间间隔接受测试。在这三个阶段中的任何一个阶段，这些组之间在测试表现上均未发现具有统计学意义的差异。美沙酮组和对照组在记忆功能下降的主观报告频率上也没有显著差异。先前关于长期服用美沙酮期间记忆缺陷的报告可能是由于在单一时间点比较美沙酮组和对照组，并假设在美沙酮维持治疗之前两组是等效的。
