Pirttilä T, Lehtimäki T, Rinne J, Mattila K, Frey H, Nikkari T
Department of Neurology, University of Tempere, Finland.
Acta Neurol Scand. 1996 May;93(5):352-4. doi: 10.1111/j.1600-0404.1996.tb00008.x.
We used the NINDS-AIREN criteria to diagnose vascular dementia (VD), and compared apolipoprotein E (apoE) allele frequencies and apoE concentrations in serum and cerebrospinal fluid (CSF) between patients with possible (n = 19) and probable (n = 33) VD and controls (n = 105). There was no difference in apoE4 frequency between patients with probable VD and controls. Serum and CSF apoE concentrations did not differ between VD patients and controls. Our results suggest that apoE plays no role in the development of VD.
我们采用美国国立神经疾病与中风研究所-阿尔茨海默病相关神经障碍协会（NINDS-AIREN）标准诊断血管性痴呆（VD），并比较了可能患有VD（n = 19）、很可能患有VD（n = 33）的患者与对照组（n = 105）血清和脑脊液（CSF）中载脂蛋白E（apoE）等位基因频率及apoE浓度。很可能患有VD的患者与对照组之间的apoE4频率无差异。VD患者与对照组之间的血清和脑脊液apoE浓度无差异。我们的结果表明，apoE在VD的发生发展中不起作用。
