Morgenstern L, Michel S L, Austin E
Arch Surg. 1977 Aug;112(8):941-3. doi: 10.1001/archsurg.1977.01370080039005.
Microfibrillar (Avitene) is a new absorbable topical hemostatic agent whose mechanism of action is platelet entrapment and activation of platelet clotting factors. It adheres to moist tissue surfaces to form a firm, flexible hemostatic coagulum. It has been used clinically in 36 patients with hepatic bleeding of diverse etiology, including bleeding from the gallbladder fossa, lacerations, resectional surfaces, biopsy sites, capsular denudations, and hepatic tumors. Although not intended to control major hemorrhage were major vessel ligation or resection is properly indicated, its topical use for diffuse small vessel bleeding may be life-saving. It is exceptionally useful in such conditions as cirrhosis and in thrombocytopenic or thrombasthenic coagulopathies. One treatment failure out of 36 occurred.
微纤维（阿维停）是一种新型可吸收局部止血剂，其作用机制是截留血小板并激活血小板凝血因子。它粘附于湿润的组织表面，形成牢固、有弹性的止血凝块。它已在36例病因各异的肝出血患者中临床应用，包括来自胆囊窝、裂伤、切除面、活检部位、包膜剥脱和肝肿瘤的出血。尽管它并非用于控制需要适当进行大血管结扎或切除的大出血，但它局部用于弥漫性小血管出血可能挽救生命。它在肝硬化以及血小板减少或血小板功能不全的凝血病等情况下格外有用。36例中有1例治疗失败。
