Machleder H I, Barker W F
Arch Surg. 1977 Aug;112(8):944-6. doi: 10.1001/archsurg.1977.01370080042006.
Sixty-five patients with clinical evidence of carotid occlusive disease were evaluated by the Doppler ophthalamic test, ophthalmodynamography, and oculopneumoplethysmography prior to angiography. Clinical assessment was accurate 68% of the time, with 32% of patients having no arteriographic evidence of significant disease. The sensitivity of the noninvasive tests was dependent on the extent of the carotid stenosis. When the extent was greater than 60% of the cross-sectional diameter, the Doppler ophthalmic test was accurate 54% of the time; the ophthalmodynamography test, 61% of the time; and the oculopneumoplethysmographic test, 97% of the time. In lesions encompassing 50% to 60% of the vessel diameter, the Doppler ophthalmic test was accurate 15% of the time; the ophthalmodynamography test, 17% of the time; and the oculopneumoplethysmographic test, 10% of the time. With less than 50% stenosis, none of the noninvasive tests detected atherosclerotic lesions. Although many diseased vessels were missed, the low incidence of false-positive tests enhanced the usefulness of these methods in augmenting the accuracy of clinical evaluation.
65例有颈动脉闭塞性疾病临床证据的患者在血管造影术前接受了多普勒眼科检查、眼动脉血流图检查和眼空气体积描记法检查。临床评估在68%的时间内是准确的，32%的患者在动脉造影中没有明显疾病的证据。无创检查的敏感性取决于颈动脉狭窄的程度。当狭窄程度大于横截面直径的60%时，多普勒眼科检查在54%的时间内是准确的；眼动脉血流图检查在61%的时间内是准确的；眼空气体积描记法检查在97%的时间内是准确的。在血管直径累及50%至60%的病变中，多普勒眼科检查在15%的时间内是准确的；眼动脉血流图检查在17%的时间内是准确的；眼空气体积描记法检查在10%的时间内是准确的。当狭窄程度小于50%时，无创检查均未检测到动脉粥样硬化病变。虽然许多病变血管被漏诊，但假阳性检查的低发生率提高了这些方法在提高临床评估准确性方面的实用性。
