Wu J J
Human Obstetrics and Gynaecology Hospital, Changsha, People's Republic of China.
Eur J Obstet Gynecol Reprod Biol. 1996 Jan;64(1):51-4. doi: 10.1016/0301-2115(95)02270-8.
Preeclampsia and eclampsia remain one of the most serious complications of pregnancy, and the pathophysiology of the diseases is not fully understood. To investigate lipid peroxidation status in preeclamptic and eclamptic pregnancies, we measured the serum malondialdehyde (MDA) level, a product of lipid peroxide, in pregnant women with or without preeclampsia or eclampsia. Serum MDA levels were raised in women with preeclamptic (4.5 +/- 0.6 mumol/L) (P < 0.005) or eclamptic (4.9 +/- 0.8 mumol/L) (P < 0.005) pregnancies compared with uncomplicated pregnancy (3.3 +/- 0.7 mumol/L). An increased MDA level was also present in uncomplicated pregnancy compared to non-pregnant women (2.6 +/- 0.4 mumol/L) (P < 0.05). Serum MDA levels were significantly decreased at the third day post-delivery in either uncomplicated pregnancy (P < 0.05), preeclamptic pregnancy (P < 0.005) or eclamptic pregnancy (P < 0.005). A positive correlation was seen between MDA level and both systolic and diastolic blood pressure in preeclamptic and eclamptic pregnancies. These results provide further evidence that excessive lipid peroxidation may contribute to the pathophysiology and pathogenesis of preeclamptic and eclamptic pregnancies.
子痫前期和子痫仍然是妊娠最严重的并发症之一，且这些疾病的病理生理学尚未完全明了。为了研究子痫前期和子痫孕妇的脂质过氧化状态，我们测定了患有或未患有子痫前期或子痫的孕妇血清中脂质过氧化物的产物丙二醛（MDA）水平。与正常妊娠（3.3±0.7μmol/L）相比，子痫前期孕妇（4.5±0.6μmol/L）（P<0.005）或子痫孕妇（4.9±0.8μmol/L）（P<0.005）的血清MDA水平升高。与未孕女性（2.6±0.4μmol/L）相比，正常妊娠的MDA水平也有所升高（P<0.05）。无论是正常妊娠（P<0.05）、子痫前期妊娠（P<0.005）还是子痫妊娠（P<0.005），产后第三天血清MDA水平均显著降低。在子痫前期和子痫妊娠中，MDA水平与收缩压和舒张压均呈正相关。这些结果进一步证明，过度的脂质过氧化可能参与了子痫前期和子痫妊娠的病理生理学和发病机制。
