Yanik F F, Amanvermez R, Yanik A, Celik C, Kökçü A
Department of Obstetrics and Gynecology, Medical Faculty of Ondokuz Mayis University, Samsun, Turkey.
Int J Gynaecol Obstet. 1999 Jan;64(1):27-33. doi: 10.1016/s0020-7292(98)00161-1.
To evaluate lipid peroxidation and the serum levels of the antioxidant vitamin E in pre-eclampsia according to the disease severity.
Serum malondialdehyde (MDA) and vitamin E levels were measured in 18 pre-eclamptic, 15 eclamptic and 25 normotensive pregnant women in Ondokuz Mayis University Hospital. The correlation of these levels with the factors indicating disease severity was tested. Mann-Whitney U-test and correlation coefficients were used for the statistical analysis.
Both the pre-eclamptic and the eclamptic patients had higher MDA and lower vitamin E levels compared with control (P < 0.05); but these values were not significantly different from each other (P > 0.05). MDA levels were significantly correlated with the systolic and diastolic blood pressure (BP) and with serum uric acid levels. There was significant but negative correlation with the vitamin E levels.
There is an imbalance between lipid peroxidation and serum vitamin E levels in pre-eclampsia and eclampsia. Increased lipid peroxidation is well correlated with the increase in systolic and diastolic BP measurements and serum uric acid levels.
根据疾病严重程度评估子痫前期患者的脂质过氧化作用及抗氧化剂维生素E的血清水平。
在翁多库兹迈伊斯大学医院对18例子痫前期患者、15例子痫患者及25例血压正常的孕妇进行血清丙二醛（MDA）和维生素E水平检测。检验这些水平与指示疾病严重程度的因素之间的相关性。采用曼-惠特尼U检验和相关系数进行统计分析。
与对照组相比，子痫前期患者和子痫患者的MDA水平均较高，维生素E水平均较低（P < 0.05）；但这些值彼此之间无显著差异（P > 0.05）。MDA水平与收缩压和舒张压以及血清尿酸水平显著相关。与维生素E水平存在显著的负相关。
子痫前期和子痫患者的脂质过氧化作用与血清维生素E水平之间存在失衡。脂质过氧化作用增加与收缩压和舒张压测量值及血清尿酸水平升高密切相关。
