Elliott K R, Pogson C I, Smith S A
Biochem J. 1977 Apr 15;164(1):283-6. doi: 10.1042/bj1640283.
Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.
喹啉酸可被大鼠和豚鼠的肝细胞摄取。大鼠细胞在约20分钟后达到平衡，但豚鼠细胞在60分钟后仍未达到稳态。没有证据表明喹啉酸会被这两个物种迅速代谢。用0.5 mM喹啉酸短时间孵育后，大鼠和豚鼠细胞中达到的喹啉酸浓度并未抑制糖异生作用。这些结果进一步引发了对喹啉酸在肝脏中作用机制的质疑。
