肝细胞膜对喹啉酸的通透性。
Permeability of the liver cell membrane to quinolinate.
作者信息
Elliott K R, Pogson C I, Smith S A
出版信息
Biochem J. 1977 Apr 15;164(1):283-6. doi: 10.1042/bj1640283.
Abstract
Quinolinate was taken up by both rat and guinea-pig liver cells. Equilibrium was reached after approx. 20 min with rat cells, but guinea-pig cells had not achieved a steady state after 60 min. There was no evidence to suggest that quinolinate is rapidly metabolized by either species. The concentrations of quinolinate attained in rat and guinea-pig cells after short periods of incubation with 0.5 mM-quinolinate did not inhibit gluconeogenesis. These results raise further doubts as to the mechanism of quinolinate action in liver.
摘要
喹啉酸可被大鼠和豚鼠的肝细胞摄取。大鼠细胞在约20分钟后达到平衡，但豚鼠细胞在60分钟后仍未达到稳态。没有证据表明喹啉酸会被这两个物种迅速代谢。用0.5 mM喹啉酸短时间孵育后，大鼠和豚鼠细胞中达到的喹啉酸浓度并未抑制糖异生作用。这些结果进一步引发了对喹啉酸在肝脏中作用机制的质疑。
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本文引用的文献
1
THE ENZYMATIC CONVERSION OF QUINOLINATE TO NICOTINIC ACID MONONUCLEOTIDE IN MAMMALIAN LIVER.
J Biol Chem. 1964 Apr;239:1208-14.
2
Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.
Biochemistry. 1967 Jul;6(7):2129-38. doi: 10.1021/bi00859a034.
3
Removal of fatty acids from serum albumin by charcoal treatment.
J Biol Chem. 1967 Jan 25;242(2):173-81.
4
Response of phosphopyruvate carboxylase to tryptophan metabolites and metal ions.
Eur J Biochem. 1971 Dec;24(2):342-6. doi: 10.1111/j.1432-1033.1971.tb19692.x.
5
The mechanism of inhibition of phosphoenolpyruvate carboxylase by quinolinic acid.
Biochim Biophys Acta. 1972 Aug 28;276(2):543-50. doi: 10.1016/0005-2744(72)91015-7.
6
Regulation of gluconeogenesis in the guinea pig liver.
Eur J Biochem. 1970 Oct;16(2):289-302. doi: 10.1111/j.1432-1033.1970.tb01084.x.
7
Hypoglycemic action of tryptophan.
Diabetes. 1973 Sep;22(9):713-8. doi: 10.2337/diab.22.9.713.
8
Serum tryptophan level after carbohydrate ingestion: selective decline in non-albumin-bound tryptophan coincident with reduction in serum free fatty acids.
Life Sci II. 1973 Jan 22;12(2):57-64. doi: 10.1016/0024-3205(73)90027-1.
9
Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesis.
Am J Clin Nutr. 1972 Oct;25(10):1010-21. doi: 10.1093/ajcn/25.10.1010.
10
A study of the chromatographic behaviour of tryptophan metabolites and related compounds by chromatography on thin layers of silica gel. I. Qualitative separation.
J Chromatogr. 1972 Apr 5;66(2):311-9. doi: 10.1016/s0021-9673(01)82294-9.
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