Popella C, Glanz H, Kleinsasser O, Bödeker R H
Universitäts-HNO-Klinik Giessen.
HNO. 1996 Aug;44(8):456-61.
Since the pretherapeutic T and pT classification of vocal cord cancer according to the UICC has often been found to fail in a high percentage of cases, frequently resulting in an insufficient separation of the different T categories, the pT classification proposed by Glanz was applied in order to obtain a more exact and better reproducible pretreatment system. In a histopathological investigation of 223 previously untreated carcinomas of the vocal cord dating from 1978 to 1988, specimens from total and partial laryngectomies were examined by subserial sectionings. The extension of each lesion was ascertained by measuring tumor in three dimensions per millimeter and determining affected histopathological structures. Neck lymph nodes were also examined for metastases. The different tumor stages were then evaluated with the UICC T/pT classification of Glanz's pT classification. The survival rates and recurrence-free rates of both classification systems were compared. Our evaluation showed that 24% of all the vocal cord cancers studied had to be classified to a higher tumor stage. The pT classification developed by Glanz was better able to separate the different tumor categories than the UICC T/pT classification. Glanz's pT classification system, staging a glottic cancer according to its exact size and laryngeal structures involved, is a significant improvement on the UICC T and pT classification used to date.
由于根据国际抗癌联盟(UICC)对声带癌进行的治疗前T和pT分类在很多病例中常常被发现失败,经常导致不同T类别之间的区分不足,因此应用了格兰茨(Glanz)提出的pT分类,以获得更精确且可重复性更好的治疗前系统。在一项对1978年至1988年期间223例未经治疗的声带癌进行的组织病理学研究中,通过连续切片检查了全喉切除术和部分喉切除术的标本。通过每毫米在三个维度上测量肿瘤并确定受影响的组织病理学结构来确定每个病变的范围。还检查了颈部淋巴结是否有转移。然后用格兰茨的pT分类的UICC T/pT分类对不同的肿瘤阶段进行评估。比较了两种分类系统的生存率和无复发生存率。我们的评估表明,在所研究的所有声带癌中,有24%必须被分类为更高的肿瘤阶段。格兰茨开发的pT分类比UICC T/pT分类更能区分不同的肿瘤类别。格兰茨的pT分类系统根据声门癌的确切大小和所累及的喉部结构对其进行分期,是对迄今使用的UICC T和pT分类的重大改进。