我们衰老的速度有多快？随时间变化的运动表现作为一种生物标志物。
How fast do we age? Exercise performance over time as a biomarker.
作者信息
Bortz W M, Bortz W M
机构信息
Department of Medicine, University of North Carolina Medical Center, Chapel Hill, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 1996 Sep;51(5):M223-5. doi: 10.1093/gerona/51a.5.m223.
BACKGROUND
The rate of true chronologic functional change in humans has been previously obscured by inadvertent inclusion of data derived from sick or ill-conditioned individuals. The Masters athlete fulfills the need for a study cohort.
METHODS
Performance data by age were collected from recognized certifying organizations for running, rowing, and swimming events and plotted as percent decline from age 35, and a rate of decline of performance by age was plotted.
RESULTS
Close coincidence of the decay slopes of the events surveyed was observed. This rate is 0.5% per year. We argue that inasmuch as these strenuous events are subtended by most of the major body systems and are thereby rate-limited by them all, that no supporting system can decline faster than this rate.
CONCLUSION
The virtual identity of the performance slopes of the different athletic events with one another and to that of other functions including that of a central physiologic measure, VO2 max, indicates that 0.5% per year may be a basic biomarker of the aging process.
背景
人类真正按时间顺序发生的功能变化速率此前一直因无意中纳入了来自患病或身体状况不佳个体的数据而被掩盖。大师级运动员满足了研究队列的需求。
方法
从认可的认证机构收集跑步、赛艇和游泳项目按年龄划分的成绩数据，并绘制为相对于35岁时的下降百分比，同时绘制成绩随年龄的下降速率。
结果
观察到所调查项目的衰退斜率密切吻合。这个速率是每年0.5%。我们认为，由于这些剧烈运动项目受大多数主要身体系统支撑，因此都受到这些系统的速率限制，没有任何一个支持系统的衰退速度能比这个速率更快。
结论
不同体育项目的成绩斜率彼此之间以及与包括核心生理指标最大摄氧量在内的其他功能的成绩斜率几乎完全一致，这表明每年0.5%可能是衰老过程的一个基本生物标志物。
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