Zodpey S P, Maldhure B R, Shrikhande S N, Tiwari R R
Government Medical College, Nagpur.
J Indian Med Assoc. 1996 Sep;94(9):338-40.
A hospital-based pair-matched case-control study was carried out at Government Medical College Hospital, Nagpur to estimate the effectiveness of bacillus of Calmette-Guerin (BCG) vaccination against tuberculous meningitis. The study included 92 cases of tuberculous meningitis in the age group of 0-12 years and equal number of controls, matched for age, sex and socio-economic status. The protective effectiveness and prevented fraction were higher for the subjects in the age group of 0-6 years, males and subjects from upper strata of socio-economic class. The overall vaccine effectiveness and prevented fraction were estimated to be 86.54% (70.38-93.88%) and 65.54% (39.22-80.64%) respectively. Results of this study thus indicated that BCG vaccination was highly effective against tuberculous meningitis and played significant role in its prevention, in this population.
在那格浦尔政府医学院医院开展了一项基于医院的配对病例对照研究，以评估卡介苗（BCG）接种预防结核性脑膜炎的效果。该研究纳入了92例0至12岁的结核性脑膜炎病例以及数量相等的对照，对照在年龄、性别和社会经济地位方面进行了匹配。0至6岁年龄组的受试者、男性以及社会经济阶层较高的受试者的保护效果和预防率更高。总体疫苗效力和预防率估计分别为86.54%（70.38 - 93.88%）和65.54%（39.22 - 80.64%）。因此，本研究结果表明，在该人群中，卡介苗接种对结核性脑膜炎具有高度有效性，并在其预防中发挥了重要作用。
