人类同源盒基因Prox 1的结构与染色体定位

Structure and chromosomal localization of the human homeobox gene Prox 1.

作者信息

Zinovieva R D, Duncan M K, Johnson T R, Torres R, Polymeropoulos M H, Tomarev S I

机构信息

Laboratory of Molecular and Developmental Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Genomics. 1996 Aug 1;35(3):517-22. doi: 10.1006/geno.1996.0392.

DOI:10.1006/geno.1996.0392

PMID:8812486

Abstract

The genomic organization and nucleotide sequence of the human homeobox gene Prox 1 as well as its chromosomal localization have been determined. This gene spans more than 40 kb, consists of at least 5 exons, and encodes an 83-kDa protein. It shows 89% identity with the chicken sequence at the nucleotide level in the coding region, while the human and chicken proteins are 94% identical. Among the embryonic tissues analyzed (lens, brain, lung, liver, and kidney), the human Prox 1 gene is most actively expressed in the developing lens, similar to the expression pattern of the chicken Prox 1 gene. The Prox 1 gene was mapped to human chromosome 1q32.2-q32.3.

摘要

人类同源框基因Prox 1的基因组结构、核苷酸序列及其染色体定位已被确定。该基因跨度超过40 kb，至少由5个外显子组成，编码一种83 kDa的蛋白质。在编码区，它与鸡的序列在核苷酸水平上有89%的同一性，而人和鸡的蛋白质有94%的同一性。在所分析的胚胎组织（晶状体、脑、肺、肝和肾）中，人类Prox 1基因在发育中的晶状体中表达最为活跃，类似于鸡Prox 1基因的表达模式。Prox 1基因被定位到人类染色体1q32.2 - q32.3。