乙醇对大鼠血浆、心脏、主动脉、支气管和胰腺中氨基酸及相关化合物的影响。

Effect of ethanol on amino acids and related compounds in rat plasma, heart, aorta, bronchus, and pancreas.

作者信息

Abdel-Nabi R, Milakofsky L, Hofford J M, Hare T A, Vogel W H

机构信息

Department of Pharmacology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.

出版信息

Alcohol. 1996 Mar-Apr;13(2):171-4. doi: 10.1016/0741-8329(95)02031-4.

DOI:10.1016/0741-8329(95)02031-4

PMID:8814652

Abstract

The composition of 36 amino acids and related amino compounds is presented for plasma, aorta, heart, pancreas, and bronchi. The distribution pattern of these biochemicals is similar but not identical among the tissues. The effect of an acute dose of ethanol (2 g/kg, i.p.) on these amino acids and related compounds was then studied. In the plasma, alanine, arginine, aspartic acid, beta-alanine, glycine, phenylalanine, and serine are decreased. In the aorta, ammonia and taurine are decreased. In the heart, aspartic acid and leucine are decreased, and carnosine, GABA, glutamic acid, and ornithine are increased. In the pancreas, asparagine and taurine are decreased, and citrulline, cysteine, histidine, and isoleucine are increased. In the bronchi, GABA, ethanolamine, histidine, taurine, and isoleucine are decreased. A number of correlations of some compounds in plasma or tissues were found but differed often between control and ethanol-treated animals. Ethanol-induced tissue changes generally do not correlate with plasma changes and are mostly specific for a given tissue.

摘要

本文呈现了血浆、主动脉、心脏、胰腺和支气管中36种氨基酸及相关氨基化合物的组成情况。这些生物化学物质在各组织中的分布模式相似但并不完全相同。随后研究了急性剂量乙醇（2克/千克，腹腔注射）对这些氨基酸及相关化合物的影响。血浆中，丙氨酸、精氨酸、天冬氨酸、β-丙氨酸、甘氨酸、苯丙氨酸和丝氨酸减少。主动脉中，氨和牛磺酸减少。心脏中，天冬氨酸和亮氨酸减少，肌肽、γ-氨基丁酸、谷氨酸和鸟氨酸增加。胰腺中，天冬酰胺和牛磺酸减少，瓜氨酸、半胱氨酸、组氨酸和异亮氨酸增加。支气管中，γ-氨基丁酸、乙醇胺、组氨酸、牛磺酸和异亮氨酸减少。在血浆或组织中发现了一些化合物之间的多种相关性，但在对照动物和乙醇处理动物之间常常有所不同。乙醇诱导的组织变化通常与血浆变化不相关，且大多针对特定组织。