应激对大鼠不同组织中氨基酸及相关化合物的影响。

Effect of stress on amino acids and related compounds in various tissues of the rat.

作者信息

Decker R, von Stuckrad-Barre S, Milakofsky L, Hofford J M, Harris N, Vogel W H

机构信息

Department of Pharmacology, Thomas Jefferson University, Philadelphia, PA 19107, USA.

出版信息

Life Sci. 1995;57(19):1781-90. doi: 10.1016/0024-3205(95)02156-d.

DOI:10.1016/0024-3205(95)02156-d

PMID:7475920

Abstract

The composition of various amino acids and related compounds in the aorta, ventricle, atria, liver, kidney, pancreas, bronchi and adrenals of rats is presented. These patterns are qualitatively similar, but quantitatively different. Stress changed these patterns. In the aorta, alpha-aminobutyric acid and ammonia are decreased. In the ventricle, phosphoserine and red. Glutathione are increased; and ammonia, arginine, asparagine, carnosine, ethanolamine, glutamic acid, glutamine, lysine, phosphoethanolamine and taurine are decreased. In the atria, alpha-aminobutyric acid, aspartic acid, ethanolamine and red. glutathione are increased; and ammonia is decreased. In the liver, alpha-aminobutyric acid, cystine, isoleucine, red. glutathione, methionine and phenylalanine are increased. In the kidney, ethanolamine is increased; and beta - aminobutyric acid, citrulline, cystathionine, glutamic acid, glycine and tryptophan are decreased. In the pancreas, alpha-aminoadipic acid, ox. glutathione, leucine, glutamine, 1-methylhistidine, phenylalanine, phosphoserine, tryptophan and valine are increased; and ammonia, cystine and aspartic acid are decreased. In the adrenal glands, anserine, glutamic acid, glutamine and ox. glutathione are increased; and arginine is decreased. In the bronchi, ethanolamine and beta-alanine are increased and alpha-aminobutyric acid and ox. glutathione are decreased. Thus, stress affects certain amino compounds but changes are substance and tissue specific and independent of changes seen in the plasma.

摘要

本文呈现了大鼠主动脉、心室、心房、肝脏、肾脏、胰腺、支气管和肾上腺中各种氨基酸及相关化合物的组成情况。这些模式在性质上相似，但在数量上有所不同。应激改变了这些模式。在主动脉中，α-氨基丁酸和氨减少。在心室中，磷酸丝氨酸和还原型谷胱甘肽增加；而氨、精氨酸、天冬酰胺、肌肽、乙醇胺、谷氨酸、谷氨酰胺、赖氨酸、磷酸乙醇胺和牛磺酸减少。在心房中，α-氨基丁酸、天冬氨酸、乙醇胺和还原型谷胱甘肽增加；氨减少。在肝脏中，α-氨基丁酸、胱氨酸、异亮氨酸、还原型谷胱甘肽、蛋氨酸和苯丙氨酸增加。在肾脏中，乙醇胺增加；β-氨基丁酸、瓜氨酸、胱硫醚、谷氨酸、甘氨酸和色氨酸减少。在胰腺中，α-氨基己二酸、氧化型谷胱甘肽、亮氨酸、谷氨酰胺、1-甲基组氨酸、苯丙氨酸、磷酸丝氨酸、色氨酸和缬氨酸增加；氨、胱氨酸和天冬氨酸减少。在肾上腺中，鹅肌肽、谷氨酸、谷氨酰胺和氧化型谷胱甘肽增加；精氨酸减少。在支气管中，乙醇胺和β-丙氨酸增加，α-氨基丁酸和氧化型谷胱甘肽减少。因此，应激会影响某些氨基酸化合物，但变化具有物质和组织特异性，且与血浆中所见变化无关。