Kanazawa H, Kurihara N, Otsuka T, Fujii T, Tanaka S, Kudoh S, Hirata K, Takeda T
First Department of Internal Medicine, Osaka City Medical School, Japan.
Respiration. 1996;63(4):236-40. doi: 10.1159/000196552.
Interleukin-8 (IL-8) belongs to the family of chemotactic cytokines and has been shown to activate neutrophils in vitro and in vivo. In this study, we measured IL-8 concentration in the serum of patients with pulmonary emphysema or bronchial asthma. IL-8 concentration in serum of emphysema patients was significantly higher than in asthmatics; in emphysema patients it was significantly correlated with the smoking index and the annual decrease of FEV1.0. In asthmatics IL-8 concentration was below the level of detection, but was markedly increased during exacerbation of asthma. Our findings suggest that IL-8 may be one of the causal factors in these diseases.
白细胞介素-8（IL-8）属于趋化性细胞因子家族，已证实在体外和体内均可激活中性粒细胞。在本研究中，我们测定了肺气肿或支气管哮喘患者血清中的IL-8浓度。肺气肿患者血清中的IL-8浓度显著高于哮喘患者；在肺气肿患者中，它与吸烟指数及第一秒用力呼气容积（FEV1.0）的年下降率显著相关。在哮喘患者中，IL-8浓度低于检测水平，但在哮喘发作时显著升高。我们的研究结果表明，IL-8可能是这些疾病的病因之一。
