Roberts R C, Conley R, Kung L, Peretti F J, Chute D J
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.
Neuroreport. 1996 Apr 26;7(6):1214-8. doi: 10.1097/00001756-199604260-00024.
Numerous studies using in vivo imaging or light microscopic analysis of autopsy specimens have found abnormalities in the striatum of schizophrenics. Striatal tissue from the Maryland Brain Collection with short postmortem intervals was used in the present study. Electron micrographs of striatal neuropil were digitized to determine the area of dendritic spines. Spines were similar in size in both the caudate and the putamen in normal individuals. The spines in tissue from schizophrenics were also similar in size between these two regions. However, striatal spines in schizophrenics were approximately 30% smaller than in controls (p < 0.05). Since the majority of synapses in the striatum are formed with spines, this change in the schizophrenic brain may represent aberrant synaptic conductance and/or efficacy.
许多使用体内成像或尸检标本光镜分析的研究发现，精神分裂症患者的纹状体存在异常。本研究使用了马里兰脑库中死后间隔时间较短的纹状体组织。对纹状体神经毡的电子显微镜照片进行数字化处理，以确定树突棘的面积。正常个体的尾状核和壳核中的棘突大小相似。精神分裂症患者组织中的棘突在这两个区域之间大小也相似。然而，精神分裂症患者的纹状体棘突比对照组小约30%（p < 0.05）。由于纹状体中的大多数突触是由棘突形成的，因此精神分裂症大脑中的这种变化可能代表异常的突触传导和/或效能。
