Mileusnic R, Anokhin K, Rose S P
Open University, Biology Department, Milton Keynes, UK.
Neuroreport. 1996 May 17;7(7):1269-72. doi: 10.1097/00001756-199605170-00010.
Induction of c-fos occurs in the forebrain when chicks are trained on a passive avoidance task. Suppression of c-Fos protein synthesis with antisense oligodeoxynucleotides prevented long-term memory retention when injected 10-11 h before training, but not if injections were made between 3 h pre-and 3 h post-training. c-fos expression is thus necessary for long-term memory retention, presumably because of its control of induction of the signalling pathway that ultimately results in the protein synthesis subserving synaptic remodelling.
当雏鸡接受被动回避任务训练时，前脑会诱导c-fos的产生。在训练前10 - 11小时注射反义寡脱氧核苷酸抑制c-Fos蛋白合成会阻止长期记忆的保留，但在训练前3小时至训练后3小时之间注射则不会。因此，c-fos表达对于长期记忆的保留是必要的，大概是因为它控制了最终导致支持突触重塑的蛋白质合成的信号通路的诱导。
