Schneemann A, Schneider P A, Lipkin W I
Laboratory for Neurovirology, Department of Neurology, University of California-Irvine 92717, USA.
Uirusu. 1995 Dec;45(2):165-74. doi: 10.2222/jsv.45.165.
Borna disease virus (BDV) is a neurotropic agent that causes disturbances in movement and behavior in vertebrate host species ranging from birds to primates. Although the virus has not been isolated from human subjects, there is indirect evidence to suggest that humans with neuropsychiatric disorders may be infected with BDV. Recently, virus particles have been isolated and the viral genomic RNA has been cloned. This analysis revealed that BDV is a nonsegmented, negative-strand RNA virus. Unusual features such as RNA splicing, overlap of transcription units and transcription signals, as well as sequence dissimilarity for four of five major open reading frames to genes of other nonsegmented, negative-strand RNA viruses suggest that BDV is likely to represent a new taxon within the order Mononegavirales.
博尔纳病病毒（BDV）是一种嗜神经因子，可在从鸟类到灵长类等多种脊椎动物宿主中引起运动和行为障碍。尽管尚未从人类受试者中分离出该病毒，但有间接证据表明患有神经精神疾病的人可能感染了BDV。最近，已分离出病毒颗粒并克隆了病毒基因组RNA。该分析表明，BDV是一种不分节段的负链RNA病毒。诸如RNA剪接、转录单位和转录信号重叠等异常特征，以及五个主要开放阅读框中的四个与其他不分节段的负链RNA病毒基因的序列差异，表明BDV可能代表单股负链RNA病毒目内的一个新分类群。
