难治性癫痫患者中的不明原因猝死。
Sudden unexplained death among subjects with refractory epilepsy.
作者信息
Derby L E, Tennis P, Jick H
机构信息
Boston Collaborative Drug Surveillance Program, Boston University Medical Center, Lexington, Massachusetts, MA 02173, USA.
出版信息
Epilepsia. 1996 Oct;37(10):931-5. doi: 10.1111/j.1528-1157.1996.tb00529.x.
PURPOSE
To address concerns about possible increases in rates of sudden unexplained death (SUD) after use of new anticonvulsants, more information on the rate of SUD among subjects with refractory epilepsy is needed to provide a comparison.
METHODS
We conducted a study to estimate the incidence of SUD among subjects younger than 50 years with refractory epilepsy, by using information from the General Practice Research Database (GPRD) in the United Kingdom. For the purposes of this study, subjects receiving two or more anticonvulsant drugs concurrently were considered to have refractory epilepsy. Potential cases of SUD were identified from the computer records, and clinical records for these subjects were reviewed by two specialists in SUD in epilepsy.
RESULTS
Fifteen subjects (eight male, seven female) of the 4,150 subjects with refractory epilepsy were considered to have definite/probable or possible SUD.
CONCLUSIONS
The overall incidence rate of SUD in the population was 2.2 per 1,000 person-years (95% CI, 1.3-3.6). The rate for subjects with highly probable SUD was 1.5 per 1,000 person-years (95% CI, 0.8-2.7).
目的
为解决对使用新型抗惊厥药物后不明原因猝死（SUD）发生率可能增加的担忧，需要更多关于难治性癫痫患者中SUD发生率的信息以作比较。
方法
我们利用英国全科医疗研究数据库（GPRD）的信息进行了一项研究，以估计50岁以下难治性癫痫患者中SUD的发生率。在本研究中，同时接受两种或更多抗惊厥药物治疗的患者被视为患有难治性癫痫。从计算机记录中识别出潜在的SUD病例，并由两位癫痫SUD专家对这些患者的临床记录进行审查。
结果
在4150例难治性癫痫患者中，有15例（8例男性，7例女性）被认为患有确诊/疑似或可能的SUD。
结论
该人群中SUD的总体发生率为每1000人年2.2例（95%置信区间，1.3 - 3.6）。高度疑似SUD患者的发生率为每1000人年1.5例（95%置信区间，0.8 - 2.7）。
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