Curhan G C, Chertow G M, Willett W C, Spiegelman D, Colditz G A, Manson J E, Speizer F E, Stampfer M J
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Circulation. 1996 Sep 15;94(6):1310-5. doi: 10.1161/01.cir.94.6.1310.
Low birth weight has been associated with an increased risk of hypertension, and high birth weight has been associated with increased adult body mass index. Published studies on adults have included only a small number of women.
We studied 71 100 women in the Nurses Health Study I (NHS I) who were 30 to 55 years of age in 1976 and 92 940 women in the Nurses' Health Study II (NHS II) who were 25 to 42 years of age in 1989. Information on birth weight, blood pressure, physician-diagnosed hypertension, and other relevant variables was collected by biennial mailed questionnaire. Ninety-five percent of the women were white. Compared with women in the middle category of birth weight (NHS I, 7.1 to 8.5 lb; NHS II, 7.0 to 8.4 lb), the age-adjusted odds ratio of hypertension in NHS I women with birth weights < 5.0 lb was 1.39 (95% CI, 1.29 to 1.50); in NHS II, for birth weights < 5.5 lb, the age-adjusted odds ratio was 1.43 (95% CI, 1.31 to 1.56). There was no material change in the estimates after adjustment for other risk factors. In addition, compared with women in NHS I who weighed 7.1 to 8.5 lb at birth, those who weighed > 10 lb had an age-adjusted odds ratio of 1.62 (95% CI, 1.38 to 1.90) of being in the highest (> 29.2 kg/m2) versus the lowest (< 21.9 kg/ m2) quintile of body mass index in midlife. Similar results were seen in the NHS II cohort.
Early life exposures affecting birth weight may be important in the development of hypertension and obesity in adults.
低出生体重与高血压风险增加相关，而高出生体重与成人身体质量指数增加相关。已发表的关于成年人的研究仅纳入了少数女性。
我们在护士健康研究I（NHS I）中研究了71100名女性，她们在1976年年龄为30至55岁；在护士健康研究II（NHS II）中研究了92940名女性，她们在1989年年龄为25至42岁。通过每两年邮寄一次问卷收集出生体重、血压、医生诊断的高血压及其他相关变量的信息。95%的女性为白人。与出生体重处于中等范围的女性（NHS I，7.1至8.5磅；NHS II，7.0至8.4磅）相比，NHS I中出生体重<5.0磅的女性经年龄调整后的高血压比值比为1.39（95%可信区间，1.29至1.50）；在NHS II中，出生体重<5.5磅时，经年龄调整后的比值比为1.43（95%可信区间，1.31至1.56）。在对其他风险因素进行调整后，估计值无实质性变化。此外，与NHS I中出生时体重为7.1至8.5磅的女性相比，出生时体重>10磅的女性在中年时处于体重指数最高（>29.2 kg/m²）与最低（<21.9 kg/m²）五分位数的经年龄调整后的比值比为1.62（95%可信区间，1.38至1.90）。在NHS II队列中也观察到了类似结果。
影响出生体重的早期生活暴露可能在成人高血压和肥胖的发生发展中起重要作用。
