Curhan G C, Willett W C, Rimm E B, Spiegelman D, Ascherio A L, Stampfer M J
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Circulation. 1996 Dec 15;94(12):3246-50. doi: 10.1161/01.cir.94.12.3246.
Low birth weight has been associated with several chronic diseases in adults, including hypertension, diabetes mellitus, and obesity. Further study of these diseases in a large cohort with information on a wide variety of risk factors is essential to determine more precisely the risks associated with birth weight.
We examined the relation between birth weight and cumulative incidence of adult hypertension, incidence of non-insulin-dependent diabetes mellitus, and prevalence of obesity in a cohort of 22,846 US men (Health Professionals Follow-up Study). Birth weights, medical histories, family histories, and other factors were collected by biennial mailed questionnaires. Logistic regression was used to examine the association between birth weight and these chronic adult diseases. Low birth weight was associated with an increased risk of hypertension and diabetes; high birth weight was associated with an increased risk of obesity. Compared with men in the referent birth weight category (7.0 to 8.4 lb), men who weighed < 5.5 lb had an age-adjusted odds ratio for hypertension of 1.26 (95% confidence interval [CI], 1.11 to 1.44) and for diabetes mellitus of 1.75 (95% CI, 1.21 to 2.54). There was no material change after controlling for adult body mass index and parental histories of hypertension and diabetes mellitus. Compared with men in the referent group, the age-adjusted odds ratio of being in the highest versus the lowest quintile of adult body mass index for men with birth weight > or = 10.0 lb was 2.08 (95% CI, 1.73 to 2.50).
These findings support the hypothesis that early life exposures, for which birth weight is a marker, are associated with several chronic diseases in adulthood.
低出生体重与成人的多种慢性疾病相关，包括高血压、糖尿病和肥胖症。在一个包含各种风险因素信息的大型队列中对这些疾病进行进一步研究，对于更精确地确定与出生体重相关的风险至关重要。
我们在一个由22846名美国男性组成的队列（健康专业人员随访研究）中，研究了出生体重与成人高血压累积发病率、非胰岛素依赖型糖尿病发病率以及肥胖症患病率之间的关系。通过每两年邮寄一次的问卷收集出生体重、病史、家族史和其他因素。采用逻辑回归分析出生体重与这些成人慢性疾病之间的关联。低出生体重与高血压和糖尿病风险增加相关；高出生体重与肥胖症风险增加相关。与出生体重参考类别（7.0至8.4磅）的男性相比，体重<5.5磅的男性患高血压的年龄调整比值比为1.26（95%置信区间[CI]，1.11至1.44），患糖尿病的比值比为1.75（95%CI，1.21至2.54）。在控制了成人身体质量指数以及父母的高血压和糖尿病病史后，结果没有实质性变化。与参考组男性相比，出生体重>或=10.0磅的男性，处于成人身体质量指数最高五分位数与最低五分位数的年龄调整比值比为2.08（95%CI，1.73至2.50）。
这些发现支持了这样一种假设，即出生体重作为早期生活暴露的一个标志，与成年期的多种慢性疾病相关。
