Noia G, Littarru G P, De Santis M, Oradei A, Mactromarino C, Trivellini C, Caruso A
Department of Obstetrics and Gynecology, Catholic University, Rome, Italy.
Fetal Diagn Ther. 1996 Jul-Aug;11(4):264-70. doi: 10.1159/000264313.
Our objectives were to assess the plasma coenzyme Q10 (CoQ10) levels in normal pregnancy, in pregnancy with a spontaneous contractile event, in spontaneous abortion and in threatened abortion. Six hundred and fifteen CoQ10 levels were analyzed in 483 pregnant women: 350 patients were employed to design a normal curve; 66 patients with spontaneous contractile activity underwent two or more CoQ10 analyses in different trimesters; 49 patients presented spontaneous abortion, and 18 patients threatened abortion. The normal curve of plasma CoQ10 levels rises during each trimester of pregnancy, while there is a correspondence between a low CoQ10 level and spontaneous abortion. Furthermore we found a statistically significant difference between the plasma CoQ10 value in spontaneous contractile activity, mainly in the third trimester. We found an increase in the plasma CoQ10 level in relation to the contractile activity of the uterine muscle. Further studies are necessary to explain the involvement of this marker on pregnancy in clinical practice.
我们的目标是评估正常妊娠、发生自然宫缩事件的妊娠、自然流产和先兆流产中血浆辅酶Q10（CoQ10）水平。对483名孕妇的615个CoQ10水平进行了分析：350名患者用于绘制正常曲线；66名有自然宫缩活动的患者在不同孕期接受了两次或更多次CoQ10分析；49名患者发生自然流产，18名患者为先兆流产。血浆CoQ10水平的正常曲线在妊娠各期均升高，而CoQ10水平低与自然流产之间存在对应关系。此外，我们发现自然宫缩活动时血浆CoQ10值之间存在统计学显著差异，主要在孕晚期。我们发现血浆CoQ10水平随着子宫肌肉的收缩活动而升高。有必要进行进一步研究以解释该标志物在临床实践中对妊娠的影响。
