Sheikh J S, Sharma M, Kunath A, Fritz D A, Glueck C J, Hess E V
Department of Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio, USA.
J Rheumatol. 1996 Jul;23(7):1288-91.
We describe 2 patients with a Sjögren-like syndrome apparently secondary to hypertriglyceridemia. Both had bilateral parotitis in addition to musculoskeletal and sicca symptoms. Parotid gland histology revealed fatty infiltration with no inflammation. Therapy with dietary modification and triglyceride lowering drugs resulted in resolution of symptoms and parotid swelling in one patient. In the 2nd patient, hypertriglyceridemia was resistant to triglyceride lowering drugs, and parotid symptoms and swelling continued unabated. Our findings suggest aggressive treatment of hyperlipidemia in pseudo-Sjögren's syndrome may result in amelioration of musculoskeletal and parotid symptoms.
我们描述了2例疑似继发于高甘油三酯血症的类干燥综合征患者。两人除了有肌肉骨骼症状和干燥症状外，均患有双侧腮腺炎。腮腺组织学检查显示有脂肪浸润但无炎症。一名患者通过饮食调整和降甘油三酯药物治疗后症状缓解，腮腺肿胀消退。在第二名患者中，高甘油三酯血症对降甘油三酯药物耐药，腮腺症状和肿胀持续未减。我们的研究结果表明，对假性干燥综合征中的高脂血症进行积极治疗可能会改善肌肉骨骼和腮腺症状。
