有丝分裂原激活蛋白激酶同源物HOG1基因控制致病性真菌白色念珠菌中的甘油积累。
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.
作者信息
San José C, Monge R A, Pérez-Díaz R, Pla J, Nombela C
机构信息
Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
出版信息
J Bacteriol. 1996 Oct;178(19):5850-2. doi: 10.1128/jb.178.19.5850-5852.1996.
Abstract
The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.
摘要
白色念珠菌HOG1基因（HOG1CA）通过对与酿酒酵母hog1δ突变体相关的渗透敏感表型进行功能互补而克隆得到。HOG1CA编码一种377个氨基酸的蛋白质，与酿酒酵母Hog1p有78%的同源性。发现白色念珠菌hog1缺失突变体对渗透胁迫敏感，并且在高渗培养基上无法积累甘油。
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