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Circulating antigens in schistosomiasis: detection of 31/32-kDa proteins in sera from patients infected with Schistosoma japonicum, S. mansoni, S. haematobium, or S. intercalatum.

作者信息

Li Y L, Idris M A, Corachan M, Han J J, Kirschfink M, Ruppel A

机构信息

Institute of Tropical Hygiene, University of Heidelberg, Germany.

出版信息

Parasitol Res. 1996;82(1):14-8. doi: 10.1007/s004360050060.

DOI:10.1007/s004360050060
PMID:8825438
Abstract

A sandwich enzyme-linked immunosorbent assay (ELISA) was developed to detect 31/32-kDa schistosome proteins as circulating antigens in sera from schistosomiasis patients. A monoclonal antibody was used as a capture antibody and rabbit antiserum raised against purified 31/32-kDa proteins was the detecting antibody. Positive results were obtained with patients infected with Schistosoma japonicum (88%; n = 69), S. mansoni (80%; n = 56), S. haematobium (100%; n = 40), or S. intercalatum (94%; n = 65). Sera from uninfected Chinese and African individuals and from Chinese patients with trichinosis, cysticercosis, or paragonimiasis did not react in the assay. This ELISA appears to be valuable in diagnosing infections by all major human schistosome species.

摘要

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本文引用的文献

1
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Schistosoma mansoni: characterization of two circulating polysaccharide antigens and the immunological response to these antigens in mouse, hamster, and human infections.曼氏血吸虫：两种循环多糖抗原的特性以及小鼠、仓鼠和人类感染中对这些抗原的免疫反应
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