Davis M, Walters J K
Pharmacol Biochem Behav. 1977 Apr;6(4):427-31. doi: 10.1016/0091-3057(77)90180-0.
The startle reflex was measured in 7 groups of 10 rats each after intraperitoneal injection of saline or 0.25, 0.50, 0.75, 1.0, 2.0, 4.0 or 8.0 mg/kg psilocybin. Low doses (0.75-2.0 mg/kg) increased startle amplitude whereas high doses (4.0-8.0 mg/kg) depressed startle. Selected low (0.71 mg/kg) or high (5.70 mg/kg) doses of psilocin also had a biphasic dose-response effect on startle comparable in magnitude to equimolar doses of psilocybin. This biphasic dose-response relationship of the indole hallucinogen, psilocybin, on startle is consistent with the hypothesis that startle is increased when the firing rates of midbrain raphe neurons are selectively inhibited but is depressed when neurons postsynaptic to raphe cells are also inhibited.
在向每组10只大鼠腹腔注射生理盐水或0.25、0.50、0.75、1.0、2.0、4.0或8.0mg/kg的裸盖菇素后，对7组大鼠的惊吓反射进行了测量。低剂量（0.75 - 2.0mg/kg）会增加惊吓幅度，而高剂量（4.0 - 8.0mg/kg）则会抑制惊吓。选定的低剂量（0.71mg/kg）或高剂量（5.70mg/kg）的脱磷酸裸盖菇素对惊吓也有双相剂量反应效应，其幅度与等摩尔剂量的裸盖菇素相当。吲哚类致幻剂裸盖菇素对惊吓的这种双相剂量反应关系与以下假设一致：当中脑缝际核神经元的放电频率被选择性抑制时，惊吓会增加，但当缝际核细胞的突触后神经元也被抑制时，惊吓会受到抑制。
