Becker Y
Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
Virus Genes. 1995;11(2-3):191-5. doi: 10.1007/BF01728658.
The "immunosuppressive motif" was found to be present in the glycoproteins of retroviruses and filoviruses. This sequence is also conserved in the pathogenic lentiviruses, HIV-1 and SIV, and is absent from HIV-2 gp41 and from an apathogenic simian retrovirus. The present analysis deals with the possible involvement of the "immunosuppresessive motif" in the pathogenicity of retroviruses and filoviruses, and the reasons for the conservation of this motif. The ancestral gene from which the "immunosuppressive motif" originated is not known.
人们发现“免疫抑制基序”存在于逆转录病毒和丝状病毒的糖蛋白中。该序列在致病性慢病毒HIV-1和SIV中也保守存在，而在HIV-2 gp41以及一种无致病性的猿猴逆转录病毒中则不存在。本分析探讨了“免疫抑制基序”在逆转录病毒和丝状病毒致病性中的可能作用，以及该基序保守存在的原因。目前尚不清楚“免疫抑制基序”起源的祖先基因。
