Perona G, Cellerino R, Guidi G C, Moschini G, Stievano B M, Tregnaghi C
Scand J Haematol. 1977 Jul;19(1):116-20. doi: 10.1111/j.1600-0609.1977.tb02728.x.
Erythrocytic glutathione-peroxidase (GSH-Px) activity and plasma selenium concentrations were measured in 14 patients: 7 with iron deficiency and 7 with raised serum iron levels. The decreased enzymatic activity in iron deficiency was confirmed. Plasma selenium was significantly lower in patients with lower serum iron; furthermore there is a significant correlation between serum iron and plasma selenium concentrations. Another correlation even more significant was found between plasma selenium and enzyme activity in all the cases we studied. These data suggests that the importance of iron for GSH-Px activity may be merely due to its relationship with selenium and that plasma selenium concentration may be of critical importance for enzyme activity.
对14例患者测定了红细胞谷胱甘肽过氧化物酶（GSH-Px）活性和血浆硒浓度：7例缺铁患者和7例血清铁水平升高患者。缺铁时酶活性降低得到证实。血清铁水平较低的患者血浆硒显著降低；此外，血清铁与血浆硒浓度之间存在显著相关性。在我们研究的所有病例中，血浆硒与酶活性之间发现了更显著的相关性。这些数据表明，铁对GSH-Px活性的重要性可能仅仅是由于其与硒的关系，并且血浆硒浓度可能对酶活性至关重要。
