Dresch C, Thevenieau D, Castro-Malaspina H, Faille A
Scand J Haematol. 1977 Jul;19(1):14-24. doi: 10.1111/j.1600-0609.1977.tb02713.x.
Cell kinetics have been studied at several periods in a patient with typical cyclic neutropenia. Peripheral blood granulocyte labelling showed an increased destruction in the preleucopenic phase. Bone marrow colony-forming cells and blood leucocyte colony forming activity were normal or above the normal range. The major abnormalities were found in sequential studies of bone marrow proliferation measured by "in vitro" 3H-thymidine flash labelling. A fall in the labelling index of promyelocytes was observed in the second part of the cycle. Incubation of normal human bone marrow cells with patient's granulocytes showed a marked decrease in 3H-thymidine incorporation, compared with incubation with the same number of normal granulocytes. Human cyclic neutropenia seems to be due to a factor secreted by abnormal polymorphonuclears inhibiting myeloid proliferation.
在一名典型周期性中性粒细胞减少症患者的几个阶段对细胞动力学进行了研究。外周血粒细胞标记显示在白细胞减少前期破坏增加。骨髓集落形成细胞和血白细胞集落形成活性正常或高于正常范围。通过“体外”3H-胸腺嘧啶闪烁标记测量骨髓增殖的连续研究中发现了主要异常。在周期的第二部分观察到早幼粒细胞标记指数下降。与用相同数量的正常粒细胞孵育相比，将正常人骨髓细胞与患者粒细胞一起孵育时，3H-胸腺嘧啶掺入量显著降低。人类周期性中性粒细胞减少症似乎是由于异常多形核细胞分泌的一种因子抑制了髓系增殖。
