隔区损伤后大鼠海马组织切片上交感神经突出生长增强。

Enhanced sympathetic neurite outgrowth on rat hippocampal tissue sections following septal lesions.

作者信息

Tian X, Scott S A, Weingartner J, Crutcher K A

机构信息

Department of Neurosurgery, University of Cincinnati Medical Center, OH 45267-0515, USA.

出版信息

Brain Res. 1996 Jun 24;725(1):111-4. doi: 10.1016/0006-8993(96)00285-5.

DOI:10.1016/0006-8993(96)00285-5

PMID:8828593

Abstract

Cryostat sections of the rat hippocampus were used as tissue culture substrates for embryonic chick sympathetic explants. Neurite outgrowth from these explants was found to be significantly greater on sections taken from animals with septal lesions as compared to those receiving sham operations. This finding suggests that septal denervation leads to hippocampal substrate changes that enhance sympathetic neurite outgrowth in vitro, perhaps analogous to the sympathetic sprouting response that occurs in vivo.

摘要

大鼠海马的低温恒温器切片被用作胚胎鸡交感神经外植体的组织培养底物。与接受假手术的动物相比，发现来自这些外植体的神经突生长在取自患有隔区损伤动物的切片上明显更大。这一发现表明，隔区去神经支配导致海马底物变化，从而在体外增强交感神经突生长，这可能类似于体内发生的交感神经发芽反应。