Foldager N, Andersen T A, Jessen F B, Ellegaard P, Stadeager C, Videbaek R, Norsk P
Danish Aerospace Medical Centre of Research, Rigshospitalet, Copenhagen, Denmark.
J Appl Physiol (1985). 1996 Jul;81(1):408-12. doi: 10.1152/jappl.1996.81.1.408.
Based on the results of head-down simulation studies and the results of parabolic flights, the hypothesis was tested that central venous pressure (CVP) in humans increases during microgravity (weightlessness) compared with during the ground-based supine position. CVP was recorded with an intravascular pressure transducer in seven healthy humans during short (20-s) periods of microgravity created by parabolic-flight maneuvers and in one astronaut before, during, and up to 3 h after launch of the Spacelab D-2 mission (Space Transport System-55). When the subjects were supine during the parabolic maneuver, CVP decreased during microgravity from 6.5 +/- 1.3 to 5.0 +/- 1.4 mmHg (P < 0.05). during the Spacelab D-2 mission, CVP was 6.2 mmHg during the initial minutes of microgravity, which was very similar to the value of 6.5 mmHg in the supine position 3.5 h before launch of the space shuttle. During the subsequent 3 h of weightlessness, CVP during rest varied between 2.0 and 6.2 mmHg. We conclude that CVP during short (20-s) and longer (3-h) periods of microgravity is close to or below that of the supine position on the ground.
基于头低位模拟研究结果和抛物线飞行结果，对以下假设进行了验证：与地面仰卧位相比，人类在微重力（失重）状态下中心静脉压（CVP）会升高。在抛物线飞行操作产生的短时间（20秒）微重力期间，用血管内压力传感器记录了7名健康人的CVP；在空间实验室D-2任务（航天飞机-55）发射前、发射期间以及发射后长达3小时内，对一名宇航员的CVP进行了记录。在抛物线飞行操作期间受试者仰卧时，微重力状态下CVP从6.5±1.3 mmHg降至5.0±1.4 mmHg（P<0.05）。在空间实验室D-2任务中，微重力最初几分钟时CVP为6.2 mmHg，这与航天飞机发射前3.5小时仰卧位时6.5 mmHg的值非常相似。在随后3小时的失重期间，休息时CVP在2.0至6.2 mmHg之间变化。我们得出结论，在短时间（20秒）和长时间（3小时）微重力期间，CVP接近或低于地面仰卧位时的CVP。
