Somody L, Fagette S, Frutoso J, Gharib C, Gauquelin G
Laboratoire de Physiologie de l'Environnement (Groupement d'Intérêt Public de l'Exercice), Faculté de Médecine Grange-Blanche, Lyon, France.
Life Sci. 1998;63(10):851-7. doi: 10.1016/s0024-3205(98)00342-7.
The way in which the cardiovascular system adapts to weightlessness is still under discussion. No data are yet available on the responses of rats during space flight, although this animal is commonly used in simulation studies. We have designed and tested a protocol to study the short term responses of the cardiovascular system to weightlessness during parabolic flight. A telemetry system was used to measure heart rate (HR) and blood pressure. It was possible to collect and record radio-signals without any interference. Microgravity caused a reduction in HR, an increase in mean arterial pressure (MAP, 7%), and a non-significant decrease in central venous pressure (CVP, 13%). The change in CVP was similar to the decrease observed in human space flight. This type of study may also be feasible for longer exposure of rats to microgravity (space flight).
心血管系统适应失重的方式仍在讨论之中。尽管大鼠常用于模拟研究，但目前尚无关于其在太空飞行期间反应的数据。我们设计并测试了一种方案，以研究心血管系统在抛物线飞行期间对失重的短期反应。使用遥测系统测量心率（HR）和血压。能够在无任何干扰的情况下收集和记录无线电信号。微重力导致心率降低、平均动脉压升高（7%），中心静脉压出现不显著下降（13%）。中心静脉压的变化与人类太空飞行中观察到的下降情况相似。这种类型的研究对于大鼠更长时间暴露于微重力环境（太空飞行）可能也是可行的。
