Samsonov M A, Paramonova E G, Frolova I A, Volkova I S, Sirota I I
Vopr Pitan. 1977 Jan-Feb(1):22-7.
In patients with ischemic heart disease (IHD) with excess body weight the excretion of catecholamines and DOPA was investigated. In patients of middle and advanced age the excretion of norepinephrine was found to be down, while in those of the young age the excretion of epinephrine and norepinephrine proved to be up. There exist a correlation between the rising level of norepinephrine and hyperlipidemia. In patients with IHD the blood serotonin content is elevated. The use of an antiatherosclerotic diet with a higher protein content tends to bring down the level of the norepinephrine and, partially, also of epinephrine excretion. With patients kept on an antiatherosclerotic diet with protein content the excretion of norepinephrine sharply decreases and that of epinephrine rises. Administration of pyridoxine superimposed upon dietary variants acts favorably on the catecholamines excretion. Under the effect of the diets in question the blood serotonin remains unchanged. The implication is that both the high- and low-protein quotas in the composition of antiatherosclerotic diets do not produce an optimal effect on the catecholamines and DOPA metabolism in patients with IHD and an excess body weight.
对患有缺血性心脏病（IHD）且体重超标的患者的儿茶酚胺和多巴排泄情况进行了研究。在中年和老年患者中，发现去甲肾上腺素的排泄量下降，而在年轻患者中，肾上腺素和去甲肾上腺素的排泄量则被证明上升。去甲肾上腺素水平升高与高脂血症之间存在相关性。IHD患者的血液血清素含量升高。采用蛋白质含量较高的抗动脉粥样硬化饮食往往会降低去甲肾上腺素水平，部分情况下也会降低肾上腺素的排泄量。对于采用含蛋白质抗动脉粥样硬化饮食的患者，去甲肾上腺素的排泄量急剧下降，而肾上腺素的排泄量上升。在饮食方案基础上给予吡哆醇对儿茶酚胺排泄有良好作用。在上述饮食的作用下，血液血清素保持不变。这意味着抗动脉粥样硬化饮食组成中的高蛋白和低蛋白配额对患有IHD且体重超标的患者的儿茶酚胺和多巴代谢均未产生最佳效果。
