[Influence of oxythiamine on the fatty acid composition of rat liver total lipid fraction and phospholipids].

Changes in the content of individual fatty acids in the total lipid fraction and phospholipids of the liver occurring under the effect of oxythiamine were studied. The fatty acids composition was determined by the method of gas chromatography. A single introduction of oxythiamine in a dose of 0.4 g/kg produced in 24 hours a deficit of essential fatty acids of the liver. Similar results were obtained with daily administration of oxythiamine at the rate of 500 gamma per animal a day, for a space of 10 days. The participation of thiamine as a substrate at one of the stages marking transformation of linolic acid and inhibition of this nonspecific function of thiamine by oxythiamine are presumed.