ORG-2766对自闭症儿童大脑事件相关电位的影响。

Effects of ORG-2766 on brain event-related potentials of autistic children.

作者信息

Verbaten M N, Kemner C, Buitelaar J K, van Ree J M, van Beijsterveld C E, van Engeland H

机构信息

Department of Psychopharmacology/Rudolf Magnus Institute for Neurosciences, Utrecht University, The Netherlands.

出版信息

Psychiatry Res. 1996 Jun 26;63(1):33-45. doi: 10.1016/0165-1781(96)89319-x.

DOI:10.1016/0165-1781(96)89319-x

PMID:8832772

Abstract

A double-blind, placebo-controlled study examined the effects of 6 weeks of treatment with the adrenocorticotropin4-9 analogue ORG-2766 (40 mg/day) on brain event-related potentials (ERPs) of autistic children. In visual and auditory oddball paradigms (with task and nontask conditions), standard (80%), target (10%), and unexpected novel stimuli (10%) were presented. ORG-2766 (a) increased the occipital P3 component of the ERP to visual targets, (b) decreased the occipital P3 component of the ERP to auditory targets, (c) did not affect visual and auditory parietal target P3 components, and (d) also did not affect the A/Pcz/300 to auditory novel stimuli. In addition, ORG-2766 treatment increased the N1 component of the ERP to task-irrelevant auditory stimuli.

摘要

一项双盲、安慰剂对照研究考察了促肾上腺皮质激素4-9类似物ORG-2766（40毫克/天）治疗6周对自闭症儿童大脑事件相关电位（ERP）的影响。在视觉和听觉oddball范式（包括任务和非任务条件）中，呈现标准刺激（80%）、目标刺激（10%）和意外的新刺激（10%）。ORG-2766：（a）增加了ERP对视觉目标的枕叶P3成分；（b）降低了ERP对听觉目标的枕叶P3成分；（c）不影响视觉和听觉顶叶目标P3成分；（d）也不影响对听觉新刺激的A/Pcz/300。此外，ORG-2766治疗增加了ERP对与任务无关的听觉刺激的N1成分。