Hegerl U, Juckel G, Schmidt L G, Rommelspacher H
Department of Psychiatry, Ludwig-Maximilians-Universität, Munich, Germany.
Psychiatry Res. 1996 Jun 26;63(1):47-55. doi: 10.1016/0165-1781(96)02796-5.
Ethanol has central serotonergic effects that may be of pathogenetic importance in a subgroup of alcohol-dependent patients with a central serotonergic hypofunction. Recent results indicate that pronounced amplitude increases of auditory evoked responses (tangential dipoles, N1/P2 component) with increasing stimulus intensity (loudness) may be an indicator of such a low serotonergic neurotransmission. Because of its serotonin-agonistic effects, ethanol can be expected to decrease this intensity dependence. Twenty-eight alcoholic patients were studied both in the intoxication phase and after 1 week of withdrawal. A reduced intensity dependence of the tangential dipole activity was observed in the intoxicated state. Correspondingly, a reduction of this parameter was found in 14 healthy subjects after an ethanol load (1 g/kg, p.o.).
乙醇具有中枢5-羟色胺能效应，这在一组存在中枢5-羟色胺能功能减退的酒精依赖患者中可能具有发病机制上的重要性。最近的结果表明，随着刺激强度（响度）增加，听觉诱发电位（切线偶极子，N1/P2成分）的幅度显著增加可能是这种低5-羟色胺能神经传递的一个指标。由于其5-羟色胺激动作用，可以预期乙醇会降低这种强度依赖性。对28名酒精性患者在醉酒期和戒断1周后进行了研究。在醉酒状态下观察到切线偶极子活动的强度依赖性降低。相应地，14名健康受试者在给予乙醇负荷（1 g/kg，口服）后也发现该参数降低。
