Lalonde R, Filali M, Bensoula A N, Lestienne F
Universite de Nancy 1, Laboratoire de Biologie et Physiologie du Comportement, Montreal, Quebec, Canada.
Neurobiol Learn Mem. 1996 Mar;65(2):113-20. doi: 10.1006/nlme.1996.0013.
Cerebellar damage occurs during developmental stages in three mutant mice (staggerer, hot-foot, and lurcher), causing disturbances in posture and equilibrium. During three tests of motor coordination, the performances of staggerer mutants was inferior to that of normal mice and did not improve with extended practice for up to 7 days of training. The sensorimotor performance of hot-foot mutants and of lurcher mutants was also lower than that of normal mice. Nevertheless, hot-foot mutants showed evidence of learning in two of the three tests and lurcher mutants in all three tests. Cerebellar atrophy in the latter two mutants did not prevent sensorimotor learning, but instead impaired their ability to reach the same level of performance as that of normal mice.
在三种突变小鼠（蹒跚、热足和蹒跚者）的发育阶段会发生小脑损伤，导致姿势和平衡紊乱。在三项运动协调测试中，蹒跚突变小鼠的表现不如正常小鼠，并且在长达7天的训练中，随着练习时间延长，其表现并未改善。热足突变小鼠和蹒跚者突变小鼠的感觉运动表现也低于正常小鼠。然而，热足突变小鼠在三项测试中的两项中显示出学习迹象，而蹒跚者突变小鼠在所有三项测试中都显示出学习迹象。后两种突变小鼠的小脑萎缩并未阻止感觉运动学习，反而损害了它们达到与正常小鼠相同表现水平的能力。
