Ganji V, Kies C V
Department of Health Science and Human Ecology, California State University, San Bernardino, CA 92407, USA.
Int J Food Sci Nutr. 1996 Mar;47(2):103-10. doi: 10.3109/09637489609012571.
The objective of this study was to investigate the effect of psyllium husk fiber supplementation to the diets of soybean and coconut oil on serum lipids in normolipidemic humans. A 28-day study was divided into four 7-day experimental periods. Dietary periods were soybean oil (SO), soybean oil plus psyllium fiber (SO + PF), coconut oil (CO) and coconut oil plus psyllium fiber (CO + PF), and were arranged to a randomized cross over design. Ten subjects consumed controlled diet containing 30% fat calories (20% from test oils and 10% from controlled diet) and 20 g per day of psyllium during fiber supplementation periods. SO + PF diet significantly reduced serum cholesterol compared with SO diet (P < 0.001). CO + PF diet significantly reduced serum cholesterol compared with CO diet (P < 0.014). Hypocholesterolemic response was greater with SO + PF compared with CO + PF (0.36 mmol 1(-1) vs 0.31 mmol 1(-1)). Reductions in low-density lipoprotein (LDL) cholesterol and apolipoprotein (apo) B were parallel to reductions of serum cholesterol. SO diet decreased, while CO diet increased serum cholesterol, LDL cholesterol and apo B. Very-low density lipoprotein cholesterol, high-density lipoprotein cholesterol and apo A-1 were unaffected by psyllium fiber and saturation of fat. Reduction of serum cholesterol was due to reduction of LDL cholesterol. Psyllium fiber supplementation lowered serum cholesterol regardless of saturation level of dietary fat.
本研究的目的是调查在血脂正常的人群饮食中添加洋车前子壳纤维对大豆油和椰子油饮食血清脂质的影响。一项为期28天的研究分为四个7天的实验阶段。饮食阶段分别为大豆油（SO）、大豆油加洋车前子纤维（SO + PF）、椰子油（CO）和椰子油加洋车前子纤维（CO + PF），采用随机交叉设计。10名受试者在纤维补充阶段食用含有30%脂肪热量（20%来自试验油，10%来自对照饮食）且每天含有20克洋车前子的对照饮食。与SO饮食相比，SO + PF饮食显著降低了血清胆固醇（P < 0.001）。与CO饮食相比，CO + PF饮食显著降低了血清胆固醇（P < 0.014）。与CO + PF相比，SO + PF的降胆固醇反应更大（0.36 mmol·L⁻¹对0.31 mmol·L⁻¹）。低密度脂蛋白（LDL）胆固醇和载脂蛋白（apo）B的降低与血清胆固醇的降低平行。SO饮食降低了血清胆固醇，而CO饮食升高了血清胆固醇、LDL胆固醇和apo B。极低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和apo A-1不受洋车前子纤维和脂肪饱和度的影响。血清胆固醇的降低是由于LDL胆固醇的降低。无论饮食脂肪的饱和水平如何，补充洋车前子纤维均可降低血清胆固醇。
