Madsen J L, Scharff O, Rabol A, Krogsgaard O W
Dept. of Clinical Physiology and Nuclear Medicine, Rigshospitalet, Copenhagen, and Glostrup Hospital, Glostrup, Denmark.
Scand J Gastroenterol. 1996 Mar;31(3):254-9. doi: 10.3109/00365529609004875.
Although the small-intestinal transit rate is generally considered to influence the urinary excretion of markers of intestinal permeability, no study has until now formally addressed the importance of this influence in humans.
Ten healthy subjects ingested a test solution containing (99m)Tc-labelled diethylenetriaminepentaacetic acid ((99)mTc-DTPA), (14)C-labelled mannitol ((14)C-mannitol), and (51)Cr-labelled ethylenediaminetetraacetic acid ((51)Cr-EDTA). After ingestion, the small-intestinal transit rate of (99)mTc-DTPA was measured with the gamma camera technique. Urine was collected for time periods of 0-2 h, 2-4 h, and 4-6 h to measure the excretion of absorbed (14)C-mannitol and (51)Cr-EDTA. Moreover, the distribution volume and plasma clearance of (14)C-mannitol and (51)Cr-EDTA were determined in each subject.
A positive correlation was found between mean small-intestinal transit time and 0- to 6-h urinary excretion of (14)C-mannitol. The study did not show any correlation between small-intestinal transit rate and 0- to 6-h urinary excretion of (51)Cr-EDTA. Urinary excretion of neither (14)C-mannitol nor (51)Cr-EDTA was affected by distribution volume or urine volume. A positive correlation was observed between plasma clearance and 0- to 6-h urinary excretion of (14)C-mannitol, whereas plasma clearance did not influence the urinary excretion of (51)Cr-EDTA.
Small-intestinal transit rate seems to have a significant effect on 0- to 6-h urinary excretion of (14)C-mannitol, whereas small intestinal transit rate does not influence the timed urinary excretion of (51)Cr-EDTA.
尽管小肠转运速率通常被认为会影响肠道通透性标志物的尿排泄，但迄今为止尚无研究正式探讨这种影响在人类中的重要性。
10名健康受试者摄入一种测试溶液，其中含有（99m）锝标记的二乙三胺五乙酸（（99）mTc-DTPA）、（14）C标记的甘露醇（（14）C-甘露醇）和（51）铬标记的乙二胺四乙酸（（51）Cr-EDTA）。摄入后，采用γ相机技术测量（99）mTc-DTPA的小肠转运速率。收集0至2小时、2至4小时和4至6小时时间段的尿液，以测量吸收的（14）C-甘露醇和（51）Cr-EDTA的排泄情况。此外，还测定了每位受试者中（14）C-甘露醇和（51）Cr-EDTA的分布容积和血浆清除率。
发现平均小肠转运时间与（14）C-甘露醇0至6小时的尿排泄之间呈正相关。该研究未显示小肠转运速率与（51）Cr-EDTA 0至6小时的尿排泄之间存在任何相关性。（14）C-甘露醇和（51）Cr-EDTA的尿排泄均不受分布容积或尿量的影响。观察到血浆清除率与（14）C-甘露醇0至6小时的尿排泄之间呈正相关，而血浆清除率不影响（51）Cr-EDTA的尿排泄。
小肠转运速率似乎对（14）C-甘露醇0至6小时的尿排泄有显著影响，而小肠转运速率不影响（51）Cr-EDTA的定时尿排泄。
