使用1%利多卡因、缓冲利多卡因和无菌水稀释剂对肌内注射头孢曲松的生物等效性和耐受性进行研究。
Investigation of bioequivalence and tolerability of intramuscular ceftriaxone injections by using 1% lidocaine, buffered lidocaine, and sterile water diluents.
作者信息
Hayward C J, Nafziger A N, Kohlhepp S J, Bertino J S
机构信息
Department of Pharmacy Services, Bassett Healthcare, Cooperstown, New York 13326, USA.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):485-7. doi: 10.1128/AAC.40.2.485.
Abstract
The pharmacokinetics and tolerability of 1-g doses of ceftriaxone diluted in sterile water, 1% lidocaine, or buffered lidocaine were investigated. No difference in bioequivalence was noted between the three treatments. No difference in peak creatine kinase values was seen. By use of a quantitative pain scale, injection of ceftriaxone with the water diluent was significantly more painful than that with either of the other two diluents. No difference in injection pain was noted for lidocaine or buffered lidocaine.
摘要
对在无菌水、1%利多卡因或缓冲利多卡因中稀释的1克剂量头孢曲松的药代动力学和耐受性进行了研究。三种治疗之间未观察到生物等效性差异。肌酸激酶峰值未观察到差异。使用定量疼痛量表时，用水稀释剂注射头孢曲松比使用其他两种稀释剂中的任何一种都明显更痛。利多卡因或缓冲利多卡因在注射疼痛方面未观察到差异。
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