含肾上腺素的中和利多卡因用于局部麻醉——II。
Neutralized lidocaine with epinephrine for local anesthesia--II.
作者信息
Stewart J H, Chinn S E, Cole G W, Klein J A
机构信息
Department of Dermatology, University of California, Irvine.
出版信息
J Dermatol Surg Oncol. 1990 Sep;16(9):842-5. doi: 10.1111/j.1524-4725.1990.tb01570.x.
The pain usually associated with intradermal injection of lidocaine and epinephrine is significantly attenuated by the addition of either sodium bicarbonate or sodium hydroxide to 1% lidocaine with epinephrine. This suggests that sodium bicarbonate attenuates pain by increasing the pH of the anesthetic solution. The clinical effects of a solution of lidocaine (1%) with epinephrine (1:100,000) and sodium bicarbonate (80 meq/L) were assessed after infiltration in skin. Anesthetic stored for 1 week caused nearly equal areas of anesthesia and vasoconstriction as an identical solution prepared on the day of use.
在1%利多卡因加肾上腺素中加入碳酸氢钠或氢氧化钠，可显著减轻皮内注射利多卡因和肾上腺素通常引起的疼痛。这表明碳酸氢钠通过提高麻醉溶液的pH值来减轻疼痛。在皮肤浸润后评估了含有肾上腺素（1:100,000）和碳酸氢钠（80 meq/L）的1%利多卡因溶液的临床效果。储存1周的麻醉剂产生的麻醉和血管收缩面积与使用当天配制的相同溶液几乎相等。
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