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Alteration of postantibiotic effect during one dosing interval of tobramycin, simulated in an in vitro pharmacokinetic model.在体外药代动力学模型中模拟的妥布霉素一个给药间隔期间抗生素后效应的改变。
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本文引用的文献

1
Action of Penicillin on Staphylococcus.青霉素对葡萄球菌的作用
J Bacteriol. 1946 Feb;51(2):181-6.
2
The post-antibiotic effect.抗生素后效应
J Antimicrob Chemother. 1993 Oct;32(4):519-37. doi: 10.1093/jac/32.4.519.
3
Postantibiotic effect of aminoglycosides on staphylococci.氨基糖苷类抗生素对葡萄球菌的抗生素后效应
J Antimicrob Chemother. 1993 Aug;32(2):215-22. doi: 10.1093/jac/32.2.215.
4
Postantibiotic effect of aminoglycosides on gram-negative bacteria evaluated by a new method.
J Antimicrob Chemother. 1988 Jul;22(1):23-33. doi: 10.1093/jac/22.1.23.
5
Once-daily dosing regimen for aminoglycoside plus beta-lactam combination therapy of serious bacterial infections: comparative trial with netilmicin plus ceftriaxone.
Am J Med. 1990 Jul;89(1):58-66. doi: 10.1016/0002-9343(90)90099-y.
6
Impact of pH and cationic supplementation on in vitro postantibiotic effect.pH值和阳离子补充对体外抗生素后效应的影响。
Antimicrob Agents Chemother. 1991 Dec;35(12):2617-24. doi: 10.1128/AAC.35.12.2617.

抗生素后效应测定过程中氨基糖苷类药物失活的酶法

Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect.

作者信息

den Hollander J G, Mouton J W, Bakker-Woudenberg I A, Vleggaar F P, van Goor M P, Verbrugh H A

机构信息

Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, Netherlands.

出版信息

Antimicrob Agents Chemother. 1996 Feb;40(2):488-90. doi: 10.1128/AAC.40.2.488.

DOI:10.1128/AAC.40.2.488
PMID:8834906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC163142/
Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

摘要

为了确定氨基糖苷类抗生素的抗生素后效应，目前使用两种方法去除受试药物：反复冲洗和稀释。我们开发了一种去除庆大霉素和妥布霉素的酶灭活方法，并与稀释法进行了比较。这种酶法提供了一种快速、简单的去除氨基糖苷类抗生素的替代方法，可得出可靠的抗生素后效应值。