抗生素后效应测定过程中氨基糖苷类药物失活的酶法
Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect.
作者信息
den Hollander J G, Mouton J W, Bakker-Woudenberg I A, Vleggaar F P, van Goor M P, Verbrugh H A
机构信息
Department of Clinical Microbiology and Antimicrobial Therapy, Erasmus University Rotterdam, Netherlands.
出版信息
Antimicrob Agents Chemother. 1996 Feb;40(2):488-90. doi: 10.1128/AAC.40.2.488.
Abstract
To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.
摘要
为了确定氨基糖苷类抗生素的抗生素后效应，目前使用两种方法去除受试药物：反复冲洗和稀释。我们开发了一种去除庆大霉素和妥布霉素的酶灭活方法，并与稀释法进行了比较。这种酶法提供了一种快速、简单的去除氨基糖苷类抗生素的替代方法，可得出可靠的抗生素后效应值。
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