Fraj J, Lezaun A, Colás C, Duce F, Domínguez M A, Alonso M D
Servicio de Alergología, Hospital Clínico, Universitario Lozano Blesa, Zaragoza, Spain.
Allergy. 1996 May;51(5):337-9. doi: 10.1111/j.1398-9995.1996.tb04619.x.
This report deals with clinical and immunologic studies in a butcher with work-related asthma. Both the positive methacholine inhalation test and the significant changes observed in PEFR measurements supported the diagnosis of asthma. The significant fall observed in PEFR measurements when the patient handled aniseed supported the diagnosis of occupational asthma. Skin prick tests carried out with 13 spices showed positive reactions only to aniseed extract. The patient had high levels of specific antianiseed IgE antibodies. The bronchial challenge test with an aniseed extract showed an immediate response without a late response. These findings suggest that the respiratory symptoms in our patient were induced by the inhalation of aniseed dust through an IgE-mediated immunologic mechanism of immediate hypersensitivity. This study established the diagnosis of occupational asthma from aniseed dust sensitization.
本报告涉及一名患有职业性哮喘的屠夫的临床和免疫学研究。乙酰甲胆碱吸入试验阳性以及呼气峰流速（PEFR）测量中观察到的显著变化均支持哮喘的诊断。当患者处理茴芹时，PEFR测量值显著下降，这支持了职业性哮喘的诊断。对13种香料进行的皮肤点刺试验仅对茴芹提取物呈阳性反应。该患者特异性抗茴芹IgE抗体水平较高。用茴芹提取物进行的支气管激发试验显示为即刻反应，无迟发反应。这些发现表明，我们患者的呼吸道症状是通过IgE介导的速发型超敏反应免疫机制，由吸入茴芹粉尘诱发的。本研究确立了由茴芹粉尘致敏引起的职业性哮喘的诊断。
