Sasaki H, Terasawa Y, Taguma Y, Hotta O, Suzuki K, Nakamura K
Division of Organ Pathophysiology, Tohoku University, Sendai, Japan.
Int Urol Nephrol. 1996;28(2):247-54. doi: 10.1007/BF02550870.
In recent years, many complications of renal cell carcinoma accompanying the increase in the number of peritoneal dialysis cases have been studied more often. Clinicopathologically, we studied comparatively cystic changes of the kidney, considered to be a background factor of cancerous development in 69 patients on peritoneal dialysis without past history of haemodialysis and in 192 patients on long-term haemodialysis. From the results, differences with respect to the duration of dialysis until the development of cysts and primary diseases commonly associated with cysts were not found between the two groups. Moreover, in the extirpated kidneys examined for cancerous development, cysts were found in both the peritoneal dialysis and the haemodialysis cases, and proliferative changes were found in the cystic epithelium. A relationship between cystic and cancerous development in the peritoneal dialysis cases was strongly suggested by these findings. Therefore, it was considered that careful follow-up studies for complications such as renal cell carcinoma would be necessary in both the peritoneal dialysis and the haemodialysis cases.
近年来，随着腹膜透析病例数的增加，肾细胞癌的许多并发症得到了更频繁的研究。从临床病理学角度，我们对69例无血液透析史的腹膜透析患者和192例长期血液透析患者的肾脏囊性变化进行了比较研究，这些囊性变化被认为是癌症发生的一个背景因素。结果显示，两组在囊肿形成前的透析时间以及与囊肿常见相关的原发性疾病方面均未发现差异。此外，在检查是否发生癌变的切除肾脏中，腹膜透析和血液透析病例均发现了囊肿，且囊肿上皮出现了增殖性变化。这些发现强烈提示腹膜透析病例中囊肿与癌变之间存在关联。因此，认为腹膜透析和血液透析病例都有必要对肾细胞癌等并发症进行仔细的随访研究。
